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Leflunomide

Uses

Leflunomide is used in the treatment of ulcerative colitis, Crohn's disease, systemic lupus erythematosus, Wilson's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, and type 2 diabetes mellitus.

How it Works

How Leflunomide works Leflunomide inhibits the action of specific chemical messengers responsible for inflammation, swelling, and redness associated with certain autoimmune diseases. It targets the underlying disease process rather than merely alleviating the symptoms.

Side Effects

Common side effects of Leflunomide include nausea, headache, rash, diarrhea, respiratory tract infection, abnormal liver enzymes, and dyspepsia.

Expert Advice

  • You have been prescribed Leflunomide to control the symptoms and slow the progression of rheumatoid arthritis.
  • It will take 6-8 weeks for Leflunomide to take effect; therefore, continue taking the medication as directed.
  • Get blood tests done every 4 weeks to ensure that Leflunomide is not adversely affecting your liver or blood counts.
  • Avoid alcohol while taking Leflunomide, as it may harm your liver.
  • Do not take Leflunomide during pregnancy or breastfeeding.
  • Inform your doctor if you become pregnant while taking Leflunomide.
  • Leflunomide may increase the risk of infection; avoid close contact with individuals who have colds, flu, or other contagious illnesses.
  • Notify your doctor if you experience nausea or diarrhea.

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Frequently asked questions

Leflunomide can cause serious side effects, including liver damage, severe infections, skin reactions, blood cell deficiency, and lung disease. Consult your doctor if you have concerns.
Leflunomide may increase the risk of certain cancers, particularly in the lymphatic system, though this is rare. Discuss any concerns with your doctor.
Yes, Leflunomide may cause minor weight loss due to a decrease in appetite. Consult your doctor if you experience significant weight loss.
Leflunomide is a disease-modifying antirheumatic drug (DMARD) that reduces inflammation and slows disease progression, benefiting patients with rheumatoid arthritis.
Avoid alcohol while taking Leflunomide, as it may increase the risk of liver toxicity.
Inform your doctor about lung issues, symptoms of infection, allergic reactions, liver problems, decreased blood cell count, or if you become pregnant during treatment.
Wait at least 2 years after stopping Leflunomide before planning pregnancy, although certain medications can reduce this time to a few weeks.
Regular blood tests to monitor blood cells and liver function, as well as blood pressure checks, are necessary during Leflunomide treatment.
Improvement may take 4 weeks or longer, with full benefits potentially seen in 4-6 months. Do not stop the medication without consulting your doctor.
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